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A positive Murphy sign can be seen with acute cholecystitis. To perform the test, palpate the gallbladder area medial to the midclavicular line while the patient is lying supine. Ask the patient to inhale deeply, which expands the lungs and pushes the gallbladder against the examiner's fingertips. The Murphy signs is considered positive if the patient abruptly ceases inhaling due to pain. Remember that the absence of a positive Murphy sign does not rule out cholecystitis! More on Acute cholecystitis: https://go.amboss.com/uss-mss Maximize your Anki benefits with AMBOSS: https://go.amboss.com/y62 Check your med school performance with the score predictor: https://go.amboss.com/uss-dhf Learn about AMBOSS for Step 1: https://go.amboss.com/uss-4219f8 Subscribe to AMBOSS YouTube for the latest clinical examination videos, medical student interviews, study tips and tricks, and live webinars! Free 5 Day Trial: https://go.amboss.com/amboss-YT Instagram: https://www.instagram.com/amboss_med/ #USMLE #MurphySign #AMBOSSMed